Introduction to Radiobiology

Introduction to Radiobiology of Targeted Radionuclide Therapy

During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellu...

Proton Radiobiology

In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly...

An Introduction to Sociolinguistics

Introduction to circular data

In many diverse scientific fields, the measurements are directions. For instance, a biologist may be measuring the direction of flight of a bird or the orientation of an animal. A series of such observations is called ”directional data”. Since a direction has no magnitude, these can be conveniently represented as points on the circumference of a unit circle centered at the origin or as unit ...

Issues in a SYSTEM approach to radiobiology

After several decades of a profoundly reductionist approach to biology the research community is now being encouraged to be more “integrative” and this includes the recommendation to adopt “a systems biology” approach. I very much endorse this advice depending on what is meant by the term “systems biology”. So instead I use the term “systems approach” for this presentation. I will try and demon...